God dedicated two chapters of the great book of Revelation to the presentation of these awsome plagues, and in Revelation 1:3 He pronounced a blessing upon all who take heed to the warnings of this book.

Who will escape the plagues? Those that have "gotten victory over the beast, and over his image, and over his mark, and over the number of his name." [REV 15:2]

When will the plagues hit? Revelation 15:8 indicates that when the judgement in the heavenly sanctuary is done, (no man can "enter" the temple to change the decisions made), then the 7 angels are given the "go ahead" to unleash the plagues. Christ says, "he that is unjust, let him be unjust still... and he that is righteous, let him be righteous still; and he that is holy, let him be holy still...." [REV 22:11-12] After complete judgement is made, the decision is locked.

When the plagues come, no one change his fate. Each one has made up his or her mind, taken the mark of the beast or accepted the seal of God. They are "set in their ways" ... permanently set. That is why it is so important to get our act together before the plagues arrive.

Plauge #1 REV 16:2 A grievous sore infects the beast and his followers.
Plauge #2 REV 16:3 The oceans turn red as blood, and poisonous.
Plauge #3 REV 16:4-7 Rivers turn to blood, but God's true people are given fresh water.
Plauge #4 REV 16:8-9 Men have chosen to worship Sunday (Sun's Day), now the sun is truely given to them.
Plauge #5 REV 16:10-11 The literal darkness symbolizes the spirtual darkness of the beast.
Plauge #6 REV 16:12-16 The great river Euphrates "dries up," symbolizing support is withdrawn from spirtual Babylon. The battle of Armageddon draws near.
Plauge #7 REV 16:17-21 The 2nd coming of Jesus takes place under the 7th plague. The large hail stones rain down on mankind, and Christ is on His way.
Not a single plague will strike the righteous. [PSA 91:10] Just as in the days of the plagues in Egypt. God's angels will personally encamp around the righteous.

How long will the plagues last? Revelation 18:8 says, "her plagues come in one day." This could indicate the suddenness with which the plagues descend upon mankind, or it could be seen as "prophetic time": a "day" would equal one literal year.